Lysosomal Sphingolipid Metabolism
Gene co-expression module in Glial cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub genes LAMP1, PSAP, and ASAH1 are canonical lysosomal components involved in sphingolipid catabolism and lysosomal membrane integrity. SGCE and SSPN are membrane-associated structural proteins. CLIC4 is a chloride channel active in endo-lysosomal acidification. SERPINB6 inhibits lysosomal cysteine proteases. The module represents a lysosomal biogenesis and sphingolipid metabolism program, upregulated in UC remission suggesting restoration of normal glial lysosomal function.
Genes
ASAH1, BEX4, CLIC4, EID1, LAMP1, PSAP, SERPINB6, SGCE, SSPN
Most correlated modules
- Glial Cytoskeletal Homeostasis · correlation 0.92
- Glial Homeostatic Identity · correlation 0.88
- Glial Myelination Identity · correlation 0.86
- Glial Identity Homeostasis · correlation 0.86
- Enteric Glial Identity · correlation 0.84
- Antioxidant Stress Response · correlation 0.83
- Glutathione Detoxification · correlation 0.83
- Myelinating Schwann Cell · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.