Glutathione Detoxification
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Dominant hub genes GSTP1 (cytosolic glutathione S-transferase) and MGST3 (microsomal glutathione S-transferase) define a glutathione-mediated detoxification program. SRP14 supports ER targeting, DAD1 is anti-apoptotic, VPS28 participates in ESCRT/vesicle sorting, and RABAC1 regulates Rab GTPases. VIM and RHOC indicate cytoskeletal remodeling context. Core coherence supports a tight detoxification module. Slightly reduced in UC inflammation, consistent with oxidative stress consuming glutathione.
Genes
DAD1, GSTP1, ITM2B, MGST3, RABAC1, RHOC, SRP14, TMA7, VIM, VPS28
Most correlated modules
- Mitochondrial OxPhos Integrity · correlation 0.92
- Antioxidant Stress Response · correlation 0.90
- Rho GTPase Signaling · correlation 0.90
- ER-Mitochondria Housekeeping · correlation 0.88
- Glial Cytoskeletal Homeostasis · correlation 0.88
- Proteasomal Proteostasis · correlation 0.88
- Nascent Polypeptide Translation · correlation 0.85
- ER Membrane Homeostasis · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.