ERAD ER Homeostasis
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
HERPUD1 (HERP) is a canonical UPR/ERAD scaffold protein upregulated by IRE1 and ATF6. DNAJB9 (ERdj4) is a PERK-target ER co-chaperone. SELENOK is an ER membrane selenoprotein involved in ERAD. SERP1 stabilizes the ribosome-translocon junction under ER stress. ATP2A2 (SERCA2) maintains ER Ca2+ levels critical for chaperone function. PGM3 generates UDP-GlcNAc for glycosylation. ARF4 and JTB participate in Golgi trafficking. This module captures ERAD machinery and ER homeostasis maintenance, distinguished from neighbor M70 (UPR chaperones) by emphasis on protein degradation and Ca2+/glycan precursor homeostasis.
Genes
ARF4, ATP2A2, C1orf122, DNAJB9, HERPUD1, JTB, LARP1B, PGM3, SELENOK, SERP1
Most correlated modules
- Mucin Folding Machinery · correlation 0.92
- ER Protein Translocation · correlation 0.88
- UPR Chaperone Response · correlation 0.87
- N-Glycosylation ER Stress · correlation 0.86
- ER Targeting ERAD · correlation 0.85
- Mucin O-Glycosylation · correlation 0.84
- Goblet Secretory Identity · correlation 0.83
- ER Chaperone Glycosylation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.