hnRNP RNA Processing
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
HNRNPAB, HNRNPD, HNRNPR are core heterogeneous nuclear ribonucleoproteins involved in pre-mRNA processing, splicing, and mRNA stability. ILF3 (NF90) binds and stabilizes mRNA. SET participates in chromatin/nucleosome assembly and RNA processing. SERBP1 regulates mRNA stability. TAF15 is an RNA-binding transcription factor. CCT2 is a chaperonin that folds RNA-binding proteins. The module represents constitutive hnRNP-mediated RNA processing.
Genes
CCT2, HNRNPAB, HNRNPD, HNRNPR, ILF3, IMPA2, SERBP1, SET, TAF15
Most correlated modules
- Chromatin RNA Regulation · correlation 0.86
- CCT Chaperonin Complex · correlation 0.83
- Chromatin Organization · correlation 0.82
- Chromatin Remodeling Repair · correlation 0.80
- Chromatin Remodeling · correlation 0.80
- Mitochondrial Homeostasis · correlation 0.80
- RNA Decay Processing · correlation 0.78
- Mitochondrial Chaperone · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.