Chromatin Remodeling
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SMARCC1 and PBRM1 are core SWI/SNF chromatin remodeling subunits. KDM1A (LSD1) is a major histone demethylase. RTF1 is part of the PAF1 transcription elongation complex. SFPQ links RNA processing to transcription. ENAH and RHOBTB3 contribute cytoskeletal/signaling support but the dominant theme across high-PageRank genes is chromatin remodeling and transcriptional regulation. Suppressed during IBD inflammation, restored with CD treatment — consistent with homeostatic transcriptional programs. Neighbor M60 also shows chromatin/transcription theme, reinforcing this classification.
Genes
CCAR1, ENAH, FNBP1L, KDM1A, LMO4, PAIP1, PBRM1, RHOBTB3, RTF1, SFPQ, SMARCC1
Most correlated modules
- Chromatin RNA Regulation · correlation 0.91
- Chromatin Remodeling · correlation 0.85
- Ion Transport Homeostasis · correlation 0.84
- Lipid Redox Homeostasis · correlation 0.84
- Progenitor Identity Program · correlation 0.84
- Adhesion & Transport · correlation 0.83
- Epithelial Maintenance · correlation 0.82
- RNA Decay Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.