Chromatin Remodeling
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
BPTF is the large subunit of the NURF chromatin remodeling complex. BAZ2B contains a bromodomain and PHD finger, functioning in chromatin regulation. TOP2B (topoisomerase II beta) resolves chromatin topology during transcription. GTF2I is a general transcription factor. RERE is a chromatin regulator/co-repressor. ZKSCAN1 is a KRAB-zinc finger transcription factor. These genes collectively define a chromatin remodeling and transcription program. Strong neighbor concordance with M74. Suppressed during inflammation and restored in CD treatment.
Genes
BAZ2B, BPTF, GTF2I, INSR, MYO10, PDZD8, RERE, TOP2B, ZKSCAN1
Most correlated modules
- Chromatin Remodeling · correlation 0.85
- Ion Transport Homeostasis · correlation 0.84
- Nuclear Architecture · correlation 0.82
- Adhesion & Transport · correlation 0.79
- Progenitor Identity Program · correlation 0.78
- Colonocyte Metabolic Defense · correlation 0.76
- RNA Splicing · correlation 0.73
- Lipid Redox Homeostasis · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.