Ubiquitin-Proteasome Degradation
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include UBE2L3 (E2 ubiquitin-conjugating enzyme), PSMA7, PSMB3, PSMB6 (proteasome subunits) pointing to ubiquitin-proteasome degradation. RHOA and ARPC5 add cytoskeletal components. GHITM is mitochondrial and TALDO1 is pentose phosphate pathway. Moderate coherence reflects a mixed but housekeeping-dominated module. Neighbor M21 and M94 share proteasome subunits confirming a proteasome-centered co-expression neighborhood. The dominant program is ubiquitin-proteasome proteolysis.
Genes
ARPC5, GAPDH, GHITM, PSMA7, PSMB3, PSMB6, RHOA, TALDO1, UBE2L3
Most correlated modules
- Proteasome Complex · correlation 0.83
- Proteostasis Housekeeping · correlation 0.78
- Oxidative Phosphorylation · correlation 0.77
- ER Protein Processing · correlation 0.77
- Sterol Biosynthesis · correlation 0.73
- Metabolic Stress Response · correlation 0.73
- Basal Transcription · correlation 0.71
- Spliceosome Assembly · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.