Proteostasis Housekeeping
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module combines multiple housekeeping programs: glycolysis (PGAM1), proteasome/ubiquitin (RBX1, ADRM1, PSMD14), translation initiation (EIF2S2), mRNA processing (MAGOHB), chaperone/folding (PFDN2, NUDC), and oxidative stress sensing (PARK7/DJ-1). NME1 (nucleoside diphosphate kinase) and OAZ1 (ornithine decarboxylase antizyme, polyamine regulation) are metabolic. TRMT112 is a tRNA methyltransferase regulating translation. The moderate coherence reflects this functional mixture. The shared thread is general proteostasis and metabolic housekeeping. As a neighbor to M47 (mitochondrial) and M7 (stress), this module likely captures the basal proteostatic machinery of goblet cells. Slight upregulation in UC inflammation may reflect compensatory protein quality control.
Genes
ADRM1, EIF2S2, GNB2, MAGOHB, NME1, NUDC, OAZ1, PARK7, PFDN2, PGAM1, PSMD14, RBX1, TRMT112
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.79
- Ubiquitin-Proteasome Degradation · correlation 0.78
- Metabolic Stress Response · correlation 0.76
- Spliceosome Assembly · correlation 0.70
- Pyroptosis Stress Response · correlation 0.70
- Basal Transcription · correlation 0.66
- Mitochondrial OxPhos · correlation 0.65
- Mucosal Innate Defense · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.