Basal Transcription
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene DYNLL1 (dynein light chain, cytoskeletal/motor) is the top PageRank gene. ACTB and ACTG1 are cytoskeletal actins. POLR2K (RNA Pol II subunit), GTF2A2 (general transcription factor), RBM8A (exon junction complex), ELOC (elongin C, transcription elongation), LSM8 (spliceosome), ENY2 (TREX-2/SAGA complex), EXOSC8 neighbor overlap. Module coherence is moderate with several weak members (LSM8, CALM2, UBB). High mean expression (1.416) and pct positive (85.7%) indicate a housekeeping program. The gene set reflects basal transcription, RNA processing, and cytoskeletal maintenance rather than a specific cell-state program. ACTB/ACTG1 and DYNLL1 contribute cytoskeletal signal; the transcriptional/splicing genes (POLR2K, GTF2A2, RBM8A, ELOC, ENY2, LSM8) dominate. This is best classified as a housekeeping module combining basal transcription and cytoskeletal maintenance. UBB (ubiquitin) further supports housekeeping. The moderate coherence and mix of programs is consistent with a promiscuous housekeeping module.
Genes
ACTB, ACTG1, CALM2, DYNLL1, ELOC, ENY2, GTF2A2, LSM8, POLR2K, RBM8A, UBB
Most correlated modules
- Ubiquitin-Proteasome Degradation · correlation 0.71
- Proteasome Complex · correlation 0.69
- Spliceosome Assembly · correlation 0.69
- S/G2 Preparation · correlation 0.69
- Oxidative Phosphorylation · correlation 0.68
- G2/M Cyclin Program · correlation 0.67
- Mitotic Proliferation · correlation 0.66
- Proteostasis Housekeeping · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.