Sterol Biosynthesis
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
FDPS (farnesyl diphosphate synthase), ACAT2 (acetoacetyl-CoA thiolase), DHCR24 (delta-24-sterol reductase), and EBP (emopamil-binding protein, sterol C8-C7 isomerase) are all enzymes in the cholesterol/sterol biosynthesis pathway. PLP2 is a proteolipid involved in membrane lipid organization. TXNDC17 provides redox support. COPS9 and CKLF are peripheral members. Upregulated significantly in UC inflammation, consistent with increased membrane remodeling or lipid raft reorganization in inflamed goblet cells. Strong coherence supports a tight sterol biosynthesis program.
Genes
ACAT2, CKLF, COPS9, DHCR24, EBP, FDPS, PLP2, TXNDC17
Most correlated modules
- Metabolic Stress Response · correlation 0.80
- Pyroptosis Stress Response · correlation 0.74
- Oxidative Phosphorylation · correlation 0.73
- Ubiquitin-Proteasome Degradation · correlation 0.73
- Electron Transport Chain · correlation 0.72
- ER Protein Processing · correlation 0.71
- Mitochondrial OxPhos · correlation 0.71
- Proteasome Complex · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.