UBE2L3 — Ubiquitin conjugating enzyme E2 L3
UBE2L3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2L3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ANAPC11, AP2S1, ATP5F1A, ATP5F1C, COPE, COX8A, GAPDH, GNG5 +7 more | View in SCUBA |
| CD4⁺ T cells | ER protein processing Protein processing & ER | EIF6, KDELR2, PDIA6, PSMC3, PSMC4, SDF2L1, SPCS2 | View in SCUBA |
| Endothelial | Glycolysis Activation Housekeeping | ATP5F1B, BSG, CCT7, COPE, FKBP3, GAPDH, ISOC2, KDELR2 +8 more | View in SCUBA |
| Gamma-delta T cells | Basal Cell Maintenance Housekeeping | ARHGDIB, CYB561D2, DNAJC8, GPAA1, INO80E, LMF2, MIF4GD, OTUB1 +9 more | |
| Goblet cells | Ubiquitin-Proteasome Degradation Housekeeping | ARPC5, GAPDH, GHITM, PSMA7, PSMB3, PSMB6, RHOA, TALDO1 | View in SCUBA |
| Innate lymphoid cells | Proteasome ER Proteostasis Protein processing & ER | ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more | View in SCUBA |
About the gene
| Synonyms | UBCH7 |
|---|---|
| Chromosome | 22: 21549447-21624034 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine; in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.