Spliceosome Assembly
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes SNRPD1, SNRPB, SNRPD3, SNRPG, SNRPF are core spliceosomal Sm proteins (snRNP components). LSM4 and LSM2 (in neighbor M27) are LSm ring proteins involved in pre-mRNA splicing and mRNA decay. RANBP1 and RAN regulate nuclear transport of splicing factors. ALYREF is an mRNA export adaptor. PPIH is a cyclophilin involved in spliceosome assembly. PTBP1 is an RNA-binding splicing regulator. The module is uniformly expressed, coherent, and fits a core spliceosomal/RNA processing program. Neighbors M27 also contains LSM2, reinforcing an RNA processing neighborhood.
Genes
ALYREF, ANAPC11, BANF1, LSM4, MRPL51, PPIH, PTBP1, RAN, RANBP1, RPA3, SNRPB, SNRPD1, SNRPD3, SNRPF, SNRPG, VPS29, YWHAH
Most correlated modules
- S/G2 Preparation · correlation 0.87
- Mitochondrial Chaperone · correlation 0.86
- CCT Chaperonin Complex · correlation 0.83
- SR Splicing Factors · correlation 0.81
- FOXM1-driven G2/M · correlation 0.80
- S-phase DNA Replication · correlation 0.77
- Mitochondrial Biogenesis · correlation 0.75
- Chromatin Organization · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.