Metabolic Stress Response
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
This module shows mixed membership and moderate coherence for several genes. COX17 (copper chaperone for CcO), CHCHD2 (mitochondrial intermembrane space), MRPL52 (mitoribosomal protein) indicate mitochondrial function. LDHA (glycolysis), ATP6V0B (V-ATPase proton pump) reflect cellular energy metabolism. TAGLN2, TPM3, WDR1 reflect actin cytoskeleton remodeling. PRDX4 is an ER-localized peroxiredoxin involved in oxidative protein folding. Upregulated in inflammation. The mitochondrial/metabolic genes dominate by PageRank (COX17, LDHA, CHCHD2) suggesting an energetic/metabolic stress response in inflamed goblet cells, with cytoskeletal remodeling as a secondary program. In the context of neighboring ER stress modules, this likely reflects increased metabolic demand.
Genes
ATP6V0B, C11orf24, CHCHD2, COX17, LDHA, MRPL52, PRDX4, SRA1, TAGLN2, TPM3, WDR1
Most correlated modules
- UPR Chaperone Response · correlation 0.86
- Mucin Folding Machinery · correlation 0.81
- Actin Cytoskeletal Remodeling · correlation 0.81
- ER Chaperone Glycosylation · correlation 0.80
- Sterol Biosynthesis · correlation 0.80
- S100 Calcium Signaling · correlation 0.79
- ER Protein Processing · correlation 0.79
- ER Targeting ERAD · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.