Proteasome Complex
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
PSMB2, PSMB5, PSMA3, PSMD7 are proteasome subunits (beta, alpha, and 19S regulatory particle). GNG5 is a G-protein gamma subunit involved in signaling. PCBD1 is a dimerization cofactor of HNF1 and pterin recycling enzyme. NDUFA4 is an accessory subunit of Complex IV. DSTN (destrin/ADF) regulates actin filament dynamics. PPP1CA is protein phosphatase 1 catalytic subunit. Moderate coherence reflects a mixed module, but proteasome subunits dominate the top PageRank positions. In the context of neighboring M46 and M21 (also proteasome-enriched), this confirms a neighborhood of proteasome activity modules. The proteasome program is labeled as primary.
Genes
DSTN, GNG5, HSBP1, NDUFA4, PCBD1, PPP1CA, PSMA3, PSMB2, PSMB5, PSMD7
Most correlated modules
- Ubiquitin-Proteasome Degradation · correlation 0.83
- ER Protein Processing · correlation 0.83
- Oxidative Phosphorylation · correlation 0.79
- CCT Chaperonin Complex · correlation 0.71
- Spliceosome Assembly · correlation 0.70
- Sterol Biosynthesis · correlation 0.69
- Basal Transcription · correlation 0.69
- SR Splicing Factors · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.