TALDO1 — Transaldolase 1

TALDO1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TALDO1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ANAPC11, AP2S1, ATP5F1A, ATP5F1C, COPE, COX8A, GAPDH, GNG5 +7 more	View in SCUBA
CD8⁺ T cells	Cellular Housekeeping Housekeeping	ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3 +9 more	View in SCUBA
Gamma-delta T cells	Complex I Assembly Mitochondrial & OxPhos	AKR7A2, AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34 +13 more
Goblet cells	Ubiquitin-Proteasome Degradation Housekeeping	ARPC5, GAPDH, GHITM, PSMA7, PSMB3, PSMB6, RHOA, UBE2L3	View in SCUBA
Hematopoietic progenitor cells	Metabolic Housekeeping Housekeeping	CRYGD, EBPL, HINT1, HSPB1, LSM7, PCBD1, PPA1, YBX3
Innate lymphoid cells	Glycolysis & OxPhos Metabolism	ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 more	View in SCUBA
Macrophages	Glycolytic Redox Metabolism Lipid metabolism	AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 more	View in SCUBA
Monocytes	Classical Monocyte Activation Inflammatory	CAPG, LGALS1, LYZ, MCEMP1, PDLIM7, S100A8, S100A9, SERPINB1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Immunoproteasome Activity Inflammation	ABRACL, ARPC5, BANF1, CARD16, CISD3, CYBC1, GIMAP2, IMP3 +4 more
Neutrophils	Actin Cytoskeleton Dynamics Cytoskeletal	ACTB, ACTG1, ARPC5, CFL1, CORO1A, ITGB2, MYL6, PFN1 +6 more

About the gene

Chromosome	11: 747415-765012
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Transferase
Biological process	Pentose shunt

Function

Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.