ER Protein Processing
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
ARPC3 and ARPC1A are Arp2/3 complex subunits (actin nucleation). POMP is a proteasome maturation chaperone; PSMA5 is a proteasome alpha subunit. SPCS1 (signal peptidase), DAD1 (oligosaccharyltransferase complex), ALG5 (dolichyl-phosphate glucosyltransferase for N-glycosylation), COPZ1 (COPI vesicle coat) together represent ER protein processing and secretory pathway components. DYNLT1 is a dynein light chain. Strong coherence. In the context of neighboring proteasome-heavy modules M46 and M94, this module bridges ER/secretory protein processing with cytoskeletal support — consistent with goblet cell secretory housekeeping. Proteasome maturation + ER processing are the dominant annotatable program.
Genes
ALG5, ARPC1A, ARPC3, COPZ1, DAD1, DYNLT1, POMP, PSMA5, SPCS1
Most correlated modules
- Mucin Folding Machinery · correlation 0.84
- Proteasome Complex · correlation 0.83
- ER Protein Translocation · correlation 0.82
- ER Chaperone Glycosylation · correlation 0.81
- Metabolic Stress Response · correlation 0.79
- Ubiquitin-Proteasome Degradation · correlation 0.77
- UPR Chaperone Response · correlation 0.75
- Oxidative Phosphorylation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.