Electron Transport Chain
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
This module is the most coherent and cleanest of the batch for mitochondrial OxPhos: NDUFS7, NDUFB7, NDUFS8, NDUFS6, NDUFB10, NDUFB1, NDUFA3, NDUFA2 are all NADH:ubiquinone oxidoreductase (Complex I) subunits; COX5B is a cytochrome c oxidase (Complex IV) subunit; UQCRC1 is a Complex III subunit; ATP5IF1 and ATP5ME are ATP synthase (Complex V) subunits. SLC25A1 is a mitochondrial citrate transporter. DCXR is a carbonyl reductase. The module strongly decreases with inflammation and recovers — classic pattern for mitochondrial OxPhos suppression during intestinal inflammation. Hub gene membership is uniformly core/strong, confirming a tight electron transport chain program.
Genes
ATP5IF1, ATP5ME, COX5B, DCXR, NDUFA2, NDUFA3, NDUFB1, NDUFB10, NDUFB7, NDUFS6, NDUFS7, NDUFS8, SLC25A1, UQCRC1
Most correlated modules
- Mitochondrial OxPhos · correlation 0.78
- Mitochondrial OxPhos · correlation 0.78
- Sterol Biosynthesis · correlation 0.72
- Mitochondrial Biogenesis · correlation 0.72
- Oxidative Phosphorylation · correlation 0.71
- Pyroptosis Stress Response · correlation 0.67
- Glutathione Detoxification · correlation 0.62
- Mucosal Innate Defense · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.