SCUBA

NDUFC2 — NADH:ubiquinone oxidoreductase subunit C2

NDUFC2 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFC2's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ANP32A, ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, GNG5, MRPL21 +10 moreView in SCUBA
CD8⁺ T cellsOxPhos & Proteasome
Mitochondrial & OxPhos
CCT8, ENY2, LSM8, NDUFV2, PPM1G, PSMC5, PSMD7, SAP18 +1 moreView in SCUBA
EnterocytesTranslation Elongation
RNA processing & translation
ATP5F1E, ATP5MC2, BTF3, EEF1A1, EEF1B2, EIF3E, NACA, PFDN5 +5 moreView in SCUBA
FibroblastsCullin-RING Ubiquitin Ligase
Housekeeping
ARPC3, LAMTOR5, MRPL51, NDUFA11, NDUFB11, OST4, RBX1, RNF7 +3 moreView in SCUBA
Gamma-delta T cellsNKG2D Cytotoxic Activation
cytotoxicity
CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2 +11 more
Goblet cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5MF, COX7A2, COX7B, COX8A, CYCS, MPC1, MPC2, NDUFC1 +3 moreView in SCUBA
Innate lymphoid cellsProteasome & COPI Trafficking
Protein processing & ER
CCT8, COPE, COPZ1, COX5A, FIBP, GPX4, LAMTOR4, MDH1 +5 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ARL2, BLOC1S1, CHMP2A, CHURC1, COX5B, DCTN3, FIS1, MRPL43 +5 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA
Mucosal-associated invariant T cellType I Interferon
Inflammation
ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2 +6 more
Smooth muscle cellsOXPHOS Complex I
Mitochondrial & OxPhos
CLTB, COPS6, ETFB, IAH1, MRPS21, NDUFA2, NDUFB10, OAT +3 moreView in SCUBA

About the gene

SynonymsB14.5b, HLC-1
Chromosome11: 78068297-78079862
Predicted locationIntracellular, Membrane
Essential geneYes
Protein classDisease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.