SR Splicing Factors
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub SRSF9 and SRSF2 are SR splicing factors; YBX1 is an mRNA-binding/splicing regulator. These define an mRNA splicing program. UQCRFS1 (Rieske Fe-S protein, Complex III), NDUFAB1 (Complex I subunit/acyl carrier protein), and GLRX5 (mitochondrial Fe-S assembly) are mitochondrial, forming a secondary sub-program. CLTA, PPP1R14B, MLEC, and TRIR are peripheral. The module is mixed but splicing factors dominate the hub positions; mitochondrial genes may co-vary due to shared housekeeping suppression during inflammation.
Genes
CLTA, GLRX5, MLEC, NDUFAB1, PPP1R14B, SRSF2, SRSF9, TRIR, UQCRFS1, YBX1
Most correlated modules
- CCT Chaperonin Complex · correlation 0.83
- Spliceosome Assembly · correlation 0.81
- Mitochondrial Chaperone · correlation 0.79
- Mitochondrial Homeostasis · correlation 0.78
- hnRNP RNA Processing · correlation 0.76
- Mitochondrial Biogenesis · correlation 0.71
- Chromatin Organization · correlation 0.71
- Mitochondrial Metabolism · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.