mRNA Translation Initiation
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by translation initiation factors (EIF3E, EIF3L, EIF3F, EIF3D), elongation factors (EEF1A1, EEF1B2), poly-A binding protein (PABPC1), and ribosome scaffold RACK1. SLC25A6 and TOMM20 provide mitochondrial energy support for translation. Core coherence, uniform expression at very high detection (93.8%), and significant downregulation in IBD inflammation with recovery on treatment is consistent with a housekeeping translation program suppressed during disease. ST13 is an HSP70 co-chaperone supporting nascent protein folding.
Genes
EEF1A1, EEF1B2, EIF3D, EIF3E, EIF3F, EIF3L, PABPC1, RACK1, SLC25A6, ST13, TOMM20
Most correlated modules
- Co-translational Chaperone · correlation 0.83
- Mitochondrial Homeostasis · correlation 0.83
- Colonocyte Differentiation Program · correlation 0.75
- Lipid Redox Homeostasis · correlation 0.75
- Ion Transport Homeostasis · correlation 0.74
- Colonocyte Metabolic Defense · correlation 0.73
- Chromatin RNA Regulation · correlation 0.73
- RNA Decay Processing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.