Chromatin RNA Regulation
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include HDAC2 (histone deacetylase), CBX1/HP1β (chromatin compaction), ANP32A (chromatin-associated), NONO (nuclear RNA processing), HNRNPM, HNRNPA0, RBMX (heterogeneous nuclear ribonucleoproteins), and KHDRBS1 (RNA-binding). The module is dominated by chromatin regulators and nuclear RNA-binding proteins. The combination of HDAC2, CBX1, ANP32A points to chromatin regulation as the primary theme, with RNA processing as secondary. Down in inflammation, up in remission — consistent with a housekeeping chromatin/gene regulation program suppressed in IBD. Neighbor M75 also involves RNA/nuclear processing, reinforcing a nuclear RNA metabolism neighborhood.
Genes
ANP32A, CBX1, HDAC2, HNRNPA0, HNRNPM, KHDRBS1, NONO, RBMX, RCN2, YWHAQ
Most correlated modules
- Chromatin Remodeling · correlation 0.91
- RNA Decay Processing · correlation 0.91
- Lipid Redox Homeostasis · correlation 0.89
- Chromatin Organization · correlation 0.88
- hnRNP RNA Processing · correlation 0.86
- Mitochondrial Homeostasis · correlation 0.84
- Progenitor Identity Program · correlation 0.84
- Colonocyte Metabolic Defense · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.