RNA Decay Processing
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
XRN2 is a 5'-3' exoribonuclease involved in transcription termination and RNA degradation. SRSF3 is a splicing factor. SYNCRIP and ILF2 are RNA-binding proteins involved in mRNA stability. YTHDF2 is an m6A reader that promotes mRNA decay. XRCC5 (Ku80) participates in DNA double-strand break repair. UBE2R2 and UBE2I are ubiquitin-conjugating enzymes involved in protein degradation. RSL24D1 is a ribosome biogenesis factor. CCNI is a cyclin. RBPJ is the Notch transcriptional effector. The dominant theme is RNA processing and post-transcriptional regulation (XRN2, SRSF3, SYNCRIP, YTHDF2, ILF2), consistent with its neighborhood relationship to M26. Down in inflammation, restored in remission.
Genes
CCNI, ILF2, RBPJ, RSL24D1, SRSF3, SYNCRIP, UBE2I, UBE2R2, XRCC5, XRN2, YTHDF2
Most correlated modules
- Chromatin RNA Regulation · correlation 0.91
- Chromatin Remodeling · correlation 0.81
- hnRNP RNA Processing · correlation 0.78
- Lipid Redox Homeostasis · correlation 0.77
- Mitochondrial Homeostasis · correlation 0.75
- Chromatin Organization · correlation 0.73
- mRNA Translation Initiation · correlation 0.71
- Ion Transport Homeostasis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.