Epithelial Maintenance
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
LAPTM4A (lysosomal membrane protein, neighbor paralog to LAPTM4B in M11) and IP6K2 (inositol polyphosphate kinase involved in apoptosis/stress) are top hubs. DDAH2 regulates nitric oxide via ADMA metabolism, relevant to epithelial NO homeostasis. MARCKS is well-documented in mucus granule secretion regulation in goblet cells. RNF44 and MKRN1 are ubiquitin E3 ligases involved in protein turnover. COX7A2L links to mitochondrial respiration. Like M11, this module is significantly downregulated in inflammation and partially restored with CD treatment, suggesting epithelial homeostatic maintenance. The neighborhood relationship with M11 (shared LAPTM4A/B paralogs, ubiquitin machinery) supports a related housekeeping/maintenance program.
Genes
COX7A2L, DDAH2, IP6K2, LAPTM4A, MARCKS, METTL9, MKRN1, RNF44
Most correlated modules
- Lipid Redox Homeostasis · correlation 0.83
- Chromatin Remodeling · correlation 0.82
- Progenitor Identity Program · correlation 0.80
- Adhesion & Transport · correlation 0.76
- Chromatin RNA Regulation · correlation 0.76
- Ion Transport Homeostasis · correlation 0.74
- Colonocyte Metabolic Defense · correlation 0.73
- Actin Dynamics · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.