Colonocyte Metabolic Defense
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 9 genes have a known function matching the annotation |
Why this annotation
ACAA2 encodes mitochondrial 3-ketoacyl-CoA thiolase (fatty acid beta-oxidation). CAT encodes catalase (antioxidant defense). MLXIP (MondoA) is a glucose-sensing transcription factor regulating metabolic gene expression. SEMA6A, SAMD5, PKDCC, GLIPR2, CRYBG1, and ZFHX3 are less well-characterized in this context. The strongest inflammation delta in this batch beyond M36 and M10. ACAA2 and CAT together suggest a metabolic/oxidative defense program. ZFHX3 is a transcription factor involved in epithelial differentiation. The module likely reflects a general colonocyte metabolic health program lost during inflammation.
Genes
ACAA2, CAT, CRYBG1, GLIPR2, MLXIP, PKDCC, SAMD5, SEMA6A, ZFHX3
Most correlated modules
- Lipid Redox Homeostasis · correlation 0.87
- Progenitor Identity Program · correlation 0.83
- Chromatin RNA Regulation · correlation 0.79
- Chromatin Remodeling · correlation 0.79
- Colonocyte Differentiation Program · correlation 0.78
- Chromatin Remodeling · correlation 0.76
- Mitochondrial Homeostasis · correlation 0.74
- Mitochondrial Metabolism · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.