Ion Transport Homeostasis
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
SLC12A2 (NKCC1) and ATP1A1 (Na/K-ATPase alpha-1) are ion transporters critical for epithelial ion and water homeostasis. CAPRIN1 and CSDE1 (UNR) are RNA-binding proteins involved in translational control and stress granule formation. EEF2 is a core translation elongation factor. VPS35 mediates endosomal retromer trafficking. APP is a transmembrane protein involved in vesicle trafficking. MAT2B links methionine metabolism. The module blends housekeeping ion transport with translational regulation. Significantly restored with CD treatment. Most concordant genes support ion homeostasis and general housekeeping.
Genes
APP, ATP1A1, CAPRIN1, CSDE1, EEF2, MAT2B, SLC12A2, TMEM123, VPS35
Most correlated modules
- Chromatin Remodeling · correlation 0.84
- Chromatin Remodeling · correlation 0.84
- Adhesion & Transport · correlation 0.81
- Chromatin RNA Regulation · correlation 0.74
- mRNA Translation Initiation · correlation 0.74
- Epithelial Maintenance · correlation 0.74
- Lipid Redox Homeostasis · correlation 0.72
- Nuclear Architecture · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.