CCT Chaperonin Complex
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
TCP1, CCT5, CCT6A are subunits of the TRiC/CCT chaperonin complex, which folds cytoskeletal and other client proteins. PTGES3 (p23) is an HSP90 co-chaperone. HNRNPA3, HNRNPC are hnRNPs co-regulated with chaperonin activity. HDGF, XRCC6, IDH2 and SRP9 are peripheral members likely co-regulated via shared proteostasis demands. The module's dominant program is the CCT/TRiC chaperonin complex supporting protein folding.
Genes
CCT5, CCT6A, HDGF, HNRNPA3, HNRNPC, IDH2, PTGES3, SMS, SRP9, TCP1, XRCC6
Most correlated modules
- Chromatin Organization · correlation 0.84
- Spliceosome Assembly · correlation 0.83
- SR Splicing Factors · correlation 0.83
- hnRNP RNA Processing · correlation 0.83
- S/G2 Preparation · correlation 0.77
- Chromatin RNA Regulation · correlation 0.74
- Mitochondrial Chaperone · correlation 0.73
- Proteasome Complex · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.