USP47 — Ubiquitin specific peptidase 47
USP47 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
USP47's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1 +24 more | |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC +14 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome Regulation Housekeeping | ABCA1, AVL9, EHMT1, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R2D +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | RAS-GEF Signaling TCR Signaling | ASCC3, FBXW7, GPATCH8, HERC1, RASGRF2, RASGRP1, TLK1, TNRC6B +2 more |
About the gene
| Chromosome | 11: 11841423-11961887 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.