Pericyte Vascular Identity
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 19 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module contains canonical pericyte vascular identity and contractility genes: NOTCH1 (arterial specification), PLXND1 (semaphorin/vascular patterning), TSPAN12 (vascular Wnt/Norrin signaling), AHR (vascular tone), PDE1C (cAMP regulation in smooth muscle), ARHGAP29 (flow-responsive Rho GTPase signaling), MEF2C (smooth muscle/vascular TF), TJP1 (junctional integrity), TMOD3 (actin dynamics), and ion transporters SLC12A2/SLC12A7/CA4 supporting cell volume and pH regulation during contractility. This represents the core pericyte vascular identity program. As a network neighbor to M42 (UC inflammatory activation), M28 defines the baseline pericyte state upon which inflammatory programs are overlaid.
Genes
AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C, PLXND1, PPFIBP1, SASH1, SLC12A2, SLC12A7, SNRK, TESC, TJP1, TMOD3, TSPAN12, ZBTB20
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.