TSPAN12 — Tetraspanin 12
TSPAN12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSPAN12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent Arterial EC Endothelial cell development | ABCG2, ANKRD50, CAMTA1, CDH23, CTNNAL1, CYB5A, HLF, INMT +10 more | View in SCUBA |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C +10 more | View in SCUBA |
About the gene
| Synonyms | NET-2, TM4SF12 |
|---|---|
| Chromosome | 7: 120787320-120858402 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Angiogenesis |
Function
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP- dependent cleavage activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.