SLC12A7 — Solute carrier family 12 member 7
SLC12A7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC12A7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2 +9 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C +10 more | View in SCUBA |
About the gene
| Synonyms | DKFZP434F076, KCC4 |
|---|---|
| Chromosome | 5: 1050384-1112063 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Potassium transport, Symport, Transport |
Function
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.