Actin Dynamics
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
Top hub genes DSTN (actin depolymerizing factor) and ARPC1A (Arp2/3 complex subunit) are canonical actin dynamics regulators. S100A6 is a calcium-binding protein linked to cytoskeletal remodeling and cell motility. PTP4A3 promotes cell migration. Together these point to an actin cytoskeletal remodeling program. MGST3, EMP3, CCND1, and NDUFA4 are peripheral members with weak/moderate membership, contributing to the moderate coherence. Slight upregulation in UC inflammation is consistent with pericyte cytoskeletal activation. Neighbor M76 also involves cytoskeletal organization (caveolae/membrane scaffolding), supporting a shared cytoskeletal neighborhood.
Genes
ARPC1A, CCND1, DSTN, EMP3, MGST3, NDUFA4, PTP4A3, S100A6
Most correlated modules
- Caveolae Organization · correlation 0.80
- ER Stress Response · correlation 0.71
- Focal Adhesion Cytoskeleton · correlation 0.70
- Myosin Phosphatase Regulation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.