Caveolae Organization
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
CAVIN1 (PTRF), CAV1, and CAV2 form the canonical caveolae biogenesis triad — CAVIN1 is essential for caveolae formation and stabilizes caveolins. UTRN (utrophin) links the actin cytoskeleton to the membrane. PLS3 (plastin-3) bundles actin filaments. SYNE2 (nesprin-2) connects the nucleus to the cytoskeleton. PDLIM5 and PLEC (plectin) are cytoskeletal scaffold/crosslinker proteins. Together this module represents caveolae-mediated membrane organization and membrane-cytoskeletal scaffolding, a known pericyte program. Strong coherence supports a tight biological program. Neighbor M37 (actin dynamics) is consistent with shared cytoskeletal membrane organization context.
Genes
CAV1, CAV2, CAVIN1, PDLIM5, PLEC, PLS3, SYNE2, UTRN
Most correlated modules
- Mitochondrial OxPhos · correlation 0.90
- ER-Actin Cytoskeletal · correlation 0.86
- Actin Dynamics · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.