MGST3 — Microsomal glutathione S-transferase 3
MGST3 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGST3's module in each cell type
About the gene
| Synonyms | GST-III |
|---|---|
| Chromosome | 1: 165631213-165661796 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Lyase, Oxidoreductase, Transferase |
| Biological process | Lipid metabolism |
Function
Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites. Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14- prostaglandin J2 to form GSH adducts relevant to the inflammatory response. Catalyzes glutathione- dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.