PTP4A3 — Protein tyrosine phosphatase 4A3
PTP4A3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTP4A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF activation survival Immune regulation | BCL2L1, CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B +12 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2 +6 more | View in SCUBA |
| Pericytes | Actin Dynamics Cytoskeletal | ARPC1A, CCND1, DSTN, EMP3, MGST3, NDUFA4, S100A6 | View in SCUBA |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, ATP10A, BBX, CDK18, CSRP2, EDNRA, GPAT2, NR3C1 +4 more | View in SCUBA |
About the gene
| Synonyms | PRL-3, PRL-R, PRL3 |
|---|---|
| Chromosome | 8: 141391995-141432454 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.