ER Stress Response
Gene co-expression module in Pericytes
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
HSPA5 (BiP/GRP78) is the master ER chaperone and canonical UPR marker. SELENOS (selenoprotein S) is an ER membrane protein involved in retrotranslocation and ER stress. SEC61G is a component of the SEC61 translocon. RAP1B is a small GTPase involved in vesicular trafficking and ER-to-Golgi transport. ARF4 is an ADP-ribosylation factor involved in Golgi trafficking. REXO2 is an RNA exonuclease. SNX6 is a sorting nexin involved in endosomal trafficking. LDHA is a glycolytic enzyme, loosely associated. PDLIM1 is a cytoskeletal PDZ-LIM protein. The dominant signal is ER stress/UPR (HSPA5, SELENOS, SEC61G) combined with vesicular trafficking (RAP1B, ARF4, SNX6). This module neighbors M70 and M40, both of which are ER folding/UPR modules, strongly supporting an ER stress identity. The upregulation in UC and CD inflammation is consistent with UPR activation. Concordant ER stress/UPR/trafficking genes: HSPA5, SELENOS, SEC61G, RAP1B, ARF4, SNX6 (6/9).
Genes
ARF4, HSPA5, LDHA, PDLIM1, RAP1B, REXO2, SEC61G, SELENOS, SNX6
Most correlated modules
- ER Protein Folding · correlation 0.95
- NF-κB Inflammatory Activation · correlation 0.93
- ER Chaperone UPR · correlation 0.92
- Inflammatory ECM Remodeling · correlation 0.86
- TGF-β Cytoskeletal Remodeling · correlation 0.81
- Basement Membrane Remodeling · correlation 0.81
- Focal Adhesion Cytoskeleton · correlation 0.80
- Basement Membrane Assembly · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.