S100A6 — S100 calcium binding protein A6

S100A6 belongs to a gene co-expression module in 17 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

S100A6's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Cytoskeleton/motility migration & adhesion	ANXA2, ANXA4, BHLHE41, C4orf48, CAPG, CAPN2, CIB1, ISCU +11 more	View in SCUBA
CD4⁺ T cells	Cell motility/adhesion migration & adhesion	ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B +14 more	View in SCUBA
CD8⁺ T cells	Gut Tissue Residency Gut residence	ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3 +9 more	View in SCUBA
Endothelial	Oxidative Stress Response Stress	AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5 +11 more	View in SCUBA
Enterocytes	High-abundance housekeeping Housekeeping	ARPC3, CD63, CYSTM1, DYNLL1, EIF1, EPCAM, H3-3A, H3-3B +1 more	View in SCUBA
Fibroblasts	Proteolytic Fibroblast State ECM remodeling	ANXA2, CTSK, EMP3, LGALS3, MPZL1, PCOLCE, ROBO1, S100A10 +3 more	View in SCUBA
Gamma-delta T cells	Effector IFN Response cytotoxicity	AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1 +9 more
Glial cells	S100 Glial Activation Activation	CDC42EP5, CREB5, CRIP2, EMP3, S100A10, S100A4, TPPP3	View in SCUBA
Goblet cells	S100 Calcium Signaling Stress	CIB1, CLDN7, CLTB, GUK1, MYL12B, MYL6, RHOC, S100A11 +4 more	View in SCUBA
Hematopoietic progenitor cells	ER Protein Folding Housekeeping	ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2 +13 more
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more	View in SCUBA
Macrophages	Inflammatory Monocyte Activation Inflammatory	ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more	View in SCUBA
Mucosal-associated invariant T cell	Leukocyte Housekeeping Housekeeping	AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG +5 more
Natural Killer cells	Granulysin Cytotoxic Effector Cytotoxicity	ARL4C, DSTN, EMP3, FLNA, GNLY, S100A4, TIMP1, VCL	View in SCUBA
Neutrophils	S100 Alarmin Response Inflammatory	CD177, H2AC6, METTL9, MS4A6A, RBP7, S100A12, S100A4, SH3BGRL3
Pericytes	Actin Dynamics Cytoskeletal	ARPC1A, CCND1, DSTN, EMP3, MGST3, NDUFA4, PTP4A3	View in SCUBA
Smooth muscle cells	MHC-I antigen presentation Inflammation	B2M, HLA-A, HLA-B, HLA-C, IFI27, NDUFA4, S100A4, TMSB4X +2 more	View in SCUBA

About the gene

Synonyms	2A9, CABP, CACY, PRA
Chromosome	1: 153534599-153536244
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.