ER Chaperone UPR
Gene co-expression module in Pericytes
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
CALR (calreticulin), PDIA6 (protein disulfide isomerase A6), PDIA3 (protein disulfide isomerase A3/ERp57), HSP90B1 (GRP94, ER Hsp90), and SSR4 (signal sequence receptor delta, translocon component) are all canonical ER chaperones and folding enzymes. PSMB5 is a proteasome subunit involved in ERAD (ER-associated degradation). RAB13 is a small GTPase involved in vesicular trafficking. HSBP1 is a heat shock factor binding protein that modulates HSF1 activity. The module is tightly co-regulated (core coherence) and uniformly expressed. Together these genes define a canonical ER proteostasis/UPR program. This is the third neighboring module with a clear ER chaperone identity (alongside M70 and M68), and the most classically 'chaperone-heavy' of the three. The inflammation upregulation is consistent with UPR induction during intestinal inflammation. Concordant ER chaperone/UPR/ERAD genes: CALR, PDIA6, PDIA3, HSP90B1, SSR4, PSMB5, HSBP1 (7/8).
Genes
CALR, HSBP1, HSP90B1, PDIA3, PDIA6, PSMB5, RAB13, SSR4
Most correlated modules
- ER Stress Response · correlation 0.92
- Immunoproteasome Induction · correlation 0.92
- ER Protein Folding · correlation 0.89
- Inflammatory ECM Remodeling · correlation 0.89
- G-protein Signaling Scaffold · correlation 0.88
- NF-κB Inflammatory Activation · correlation 0.86
- Actin Cytoskeletal Remodeling · correlation 0.85
- mRNA Stability Regulation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.