G-protein Signaling Scaffold
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes YWHAB and YWHAE are 14-3-3 family proteins — universal signaling scaffolds that bind phosphoserine/phosphothreonine motifs and regulate diverse pathways including RAS/MAPK and cell survival. RAP1A and RAC1 are small RAS-family GTPases. GNB1 and GNB2 are G-protein beta subunits that couple GPCRs to downstream effectors. BCAP29 is an ER membrane protein involved in B-cell receptor signaling scaffolding. FDPS (farnesyl diphosphate synthase) produces isoprenoid precursors required for RAS prenylation and membrane anchoring, linking it mechanistically to GTPase function. PPIA (cyclophilin A) is a weak member and likely peripheral. The module represents heterotrimeric G-protein and small GTPase signaling scaffolding, consistent with pericyte contractility and vasoregulation signaling.
Genes
BCAP29, FDPS, GNB1, GNB2, PPIA, RAC1, RAP1A, TRIR, YWHAB, YWHAE
Most correlated modules
- mRNA Stability Regulation · correlation 0.97
- RAS Cytoskeletal Signaling · correlation 0.94
- Golgi Vesicular Trafficking · correlation 0.94
- Immunoproteasome Induction · correlation 0.93
- Mitochondrial OxPhos · correlation 0.92
- RNA Splicing Processing · correlation 0.92
- ER-Actin Cytoskeletal · correlation 0.92
- Type I Interferon · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.