mRNA Stability Regulation
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub gene SET is a multifunctional protein: PP2A inhibitor, chromatin remodeler, and RNA binding. SERBP1 (SERPINE1 mRNA binding protein 1) and HNRNPK are RNA binding proteins involved in mRNA stability and translation regulation. EIF4G2 (DAP5/NAT1) is a non-canonical translation initiation factor. QKI (quaking) is an RNA binding protein regulating mRNA stability and splicing. MTDH (metadherin/AEG-1) is an oncogenic RNA binding/ER-associated protein. ACTR2 (Arp2/3 complex) and MTPN (myotrophin, actin capping) introduce a cytoskeletal component. The module is moderate coherence, combining RNA binding/translation regulation with minor cytoskeletal elements. The dominant program is post-transcriptional gene regulation.
Genes
ACTR2, EIF4G2, HNRNPK, MTDH, MTPN, QKI, SERBP1, SET
Most correlated modules
- G-protein Signaling Scaffold · correlation 0.97
- ER-Actin Cytoskeletal · correlation 0.95
- Golgi Vesicular Trafficking · correlation 0.93
- RNA Splicing Processing · correlation 0.93
- RAS Cytoskeletal Signaling · correlation 0.92
- Immunoproteasome Induction · correlation 0.92
- Type I Interferon · correlation 0.90
- Actin Cytoskeletal Remodeling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.