Immunoproteasome Induction
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
PSMB8 and PSMB9 are immunoproteasome catalytic subunits classically induced by IFN-γ, linking this module to its neighbor M14 (type I IFN). LY6E is an ISG. GRN (granulin) is a lysosomal/inflammatory mediator. CANX, TRAM1, NUCB1, TMBIM6 are ER-resident proteins involved in protein folding and ER stress. PSAP is lysosomal. PGK1 is a glycolytic enzyme upregulated under stress. The module is significantly upregulated in both UC and CD inflammation, consistent with IFN-γ-driven immunoproteasome induction combined with ER proteostasis stress. The co-expression with M14 is explained by shared IFN upstream signaling.
Genes
CANX, GRN, LY6E, NUCB1, PGK1, PSAP, PSMB8, PSMB9, SELENOW, TMBIM6, TMEM123, TRAM1
Most correlated modules
- G-protein Signaling Scaffold · correlation 0.93
- mRNA Stability Regulation · correlation 0.92
- ER Chaperone UPR · correlation 0.92
- Golgi Vesicular Trafficking · correlation 0.91
- ER-Actin Cytoskeletal · correlation 0.90
- Type I Interferon · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.88
- Inflammatory ECM Remodeling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.