Inflammatory ECM Remodeling
Gene co-expression module in Pericytes
| Category | ECM remodeling |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
This module has the strongest inflammation delta of the batch (UC: 0.566, CD: 0.468) and reverses in remission. Hub genes include: ITPRIPL2 (IP3 receptor-like, calcium signaling), PTPRE (receptor-type tyrosine phosphatase epsilon, involved in integrin signaling), NECTIN2 (cell adhesion molecule, tight junction/adherens junction), PRSS23 (serine protease, ECM remodeling), SPRY4 (Sprouty4, negative regulator of RTK/MAPK signaling), GMFG (glia maturation factor gamma, actin dynamics/migration), MARCKSL1 (MARCKS-like 1, actin cytoskeleton, membrane dynamics), LAMB1 (laminin beta-1, basement membrane ECM), OSTF1 (osteoclast stimulating factor 1, cytoskeletal remodeling), CASP4 (caspase-4, non-canonical inflammasome), RRBP1 (ribosome-binding protein 1, ER membrane), CHSY1 (chondroitin sulfate synthase 1, proteoglycan synthesis), FNDC3B (fibronectin domain-containing 3B, ECM/adhesion), OLFML2A (olfactomedin-like 2A, ECM glycoprotein). The combination of ECM components (LAMB1, CHSY1, FNDC3B, OLFML2A), cell adhesion (NECTIN2), cytoskeletal/migration regulators (GMFG, MARCKSL1, OSTF1), signaling modulators (SPRY4, PTPRE), and an inflammasome component (CASP4) suggests an inflammatory ECM remodeling and pericyte activation program. The strong inflammation upregulation and remission reversal support an active inflammatory response in pericytes. Concordant genes: NECTIN2, PRSS23, SPRY4, GMFG, MARCKSL1, LAMB1, OSTF1, CASP4, CHSY1, FNDC3B, OLFML2A, PTPRE (12/14).
Genes
CASP4, CHSY1, FNDC3B, GMFG, ITPRIPL2, LAMB1, MARCKSL1, NECTIN2, OLFML2A, OSTF1, PRSS23, PTPRE, RRBP1, SPRY4
Most correlated modules
- ER Chaperone UPR · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.86
- ER Stress Response · correlation 0.86
- TGF-β Cytoskeletal Remodeling · correlation 0.86
- ER Protein Folding · correlation 0.85
- NF-κB Inflammatory Activation · correlation 0.84
- Immunoproteasome Induction · correlation 0.80
- Basement Membrane Assembly · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.