Actin Cytoskeletal Remodeling
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
ORAI2 encodes a store-operated calcium channel subunit; FMNL3 is a formin-family actin nucleator; CDC42EP1 is a CDC42 effector regulating actin cytoskeleton; RAI14 is an actin-binding scaffold; DPYSL2 (CRMP2) regulates cytoskeletal dynamics. SHC1 is a signaling adaptor downstream of growth factor receptors. ETS1 is a transcription factor regulating pericyte/vascular programs. HDAC1 is an epigenetic regulator. LXN (latexin) is a carboxypeptidase inhibitor. The module is strongly upregulated in UC inflammation (sig.) and CD inflammation (sig.), suggesting inflammatory activation of cytoskeletal remodeling in pericytes. The calcium-actin axis (ORAI2-FMNL3-CDC42EP1-RAI14) is the dominant theme.
Genes
CDC42EP1, DPYSL2, ETS1, FMNL3, HDAC1, LXN, ORAI2, RAI14, SHC1
Most correlated modules
- RAS Cytoskeletal Signaling · correlation 0.91
- G-protein Signaling Scaffold · correlation 0.89
- Immunoproteasome Induction · correlation 0.88
- mRNA Stability Regulation · correlation 0.86
- Inflammatory ECM Remodeling · correlation 0.86
- ER Chaperone UPR · correlation 0.85
- RNA Splicing Processing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.