ER Protein Folding
Gene co-expression module in Pericytes
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes P4HB (prolyl 4-hydroxylase beta, a PDI family member), PPIB (cyclophilin B, ER peptidyl-prolyl isomerase), SSR3 (signal sequence receptor gamma, translocon component), KDELR2 (ER retention receptor), OSTC (oligosaccharyltransferase complex), and CALU (calumenin, ER Ca2+-binding protein) are all canonical ER-resident proteins involved in protein folding, glycosylation, and quality control. DYNLT1 is a dynein light chain involved in vesicular transport. AP2S1 is an adaptor protein for clathrin-mediated endocytosis. IKBIP is an IKK-interacting protein. MYDGF is a myeloid-derived growth factor secreted via the ER. The module is tightly co-regulated (core coherence), uniformly expressed, and significantly upregulated in UC and CD inflammation. This strongly points to an ER protein folding/unfolded protein response (UPR) program activated during intestinal inflammation in pericytes. Neighbor modules M68 and M40 share overlapping ER stress/UPR themes (HSPA5/BiP, CALR, PDIA3/6, HSP90B1), reinforcing this interpretation. Concordant ER/UPR genes: P4HB, PPIB, SSR3, KDELR2, OSTC, CALU, MYDGF, AP2S1 (8/10).
Genes
AP2S1, CALU, DYNLT1, IKBIP, KDELR2, MYDGF, OSTC, P4HB, PPIB, SSR3
Most correlated modules
- ER Stress Response · correlation 0.95
- Basement Membrane Remodeling · correlation 0.91
- ER Chaperone UPR · correlation 0.89
- NF-κB Inflammatory Activation · correlation 0.87
- Basement Membrane Assembly · correlation 0.86
- Focal Adhesion Cytoskeleton · correlation 0.85
- Inflammatory ECM Remodeling · correlation 0.85
- Fibrotic ECM Remodeling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.