SLC2A3 — Solute carrier family 2 member 3

SLC2A3 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SLC2A3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Hypoxia/metabolic stress Stress	ALG13, ARL4A, C9orf72, HIP1R, PDE4B, SC5D, TENT5C, VPS37B +2 more	View in SCUBA
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more	View in SCUBA
Endothelial	Notch Ligand Signaling Endothelial cell development	DLL1, ITM2A, KRT222, LTBR, MLKL, TRA2B, ZC3HAV1, ZNF436	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1 +5 more
Glial cells	BMP-SMAD Signaling Neroprotection	A2M, AQP1, ARC, CAPS, CRLF1, GDNF, ID1, ID3 +3 more	View in SCUBA
Innate lymphoid cells	IFN-driven ILC1 Activation Inflammation	AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more	View in SCUBA
Macrophages	Hypoxia-driven Activation Inflammatory	ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more	View in SCUBA
Monocytes	Inflammatory Metabolic Reprogramming Inflammatory	ACTN1, ADAM8, DGAT2, EAF1, GPAT3, MCTP2, PTPN7, SLC25A37	View in SCUBA
Mucosal-associated invariant T cell	RNA Processing Stress RNA processing & translation	DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, NAF1, RALGAPA1, SFPQ +3 more
Neutrophils	Mature Neutrophil Activation Innate immunity	AIF1, ALOX5AP, C4orf3, CD14, MCEMP1, PRELID1, TIMP1, TYMP +1 more
Pericytes	Proteotoxic Stress Response Stress	BAG3, CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, HSPH1, TRA2B +1 more	View in SCUBA

About the gene

Synonyms	GLUT3
Chromosome	12: 7919230-7936187
Predicted location	Membrane
Essential gene	No
Protein class	Metabolic proteins, Predicted membrane proteins, Transporters
Biological process	Sugar transport, Transport

Function

Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2- deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.