ZC3HAV1 — Zinc finger CCCH-type containing, antiviral 1

ZC3HAV1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ZC3HAV1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Antiviral Restriction Anti-viral	FCRL1, GLS, PPM1K, SP100, SP140L, STAT3, TGFB1, TSC22D2 +1 more	View in SCUBA
CD4⁺ T cells	mRNA Splicing Factors RNA processing	ARGLU1, CDKN2D, CLK1, ERO1B, FUS, GLS, HNRNPA2B1, ID1 +8 more	View in SCUBA
Endothelial	Notch Ligand Signaling Endothelial cell development	DLL1, ITM2A, KRT222, LTBR, MLKL, SLC2A3, TRA2B, ZNF436	View in SCUBA
Fibroblasts	Type I Interferon Inflammatory	ABHD5, HELZ2, ICAM4, IQCN, IRF7, IRF8, IRF9, LACTB +2 more	View in SCUBA
Gamma-delta T cells	Wnt-STAT3 Signaling TCR Signaling	BTBD1, COPA, CTNNB1, DHX9, EZR, HECTD1, NUP153, PAFAH1B1 +5 more
Glial cells	Proteostasis Stress Response Stress	DNAJB6, EIF5, HNRNPA0, NUDT4, RSRC2, SQSTM1, TRIM8, UBE2D3	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3 +8 more	View in SCUBA
Pericytes	Proteotoxic Stress Response Stress	BAG3, CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, HSPH1, SLC2A3 +1 more	View in SCUBA
Smooth muscle cells	BAG3-HSPB8 proteostasis Stress	BAG3, C6orf62, CREBRF, DNAJB4, EOGT, GOLGB1, HSPB8, IFRD1 +5 more	View in SCUBA

About the gene

Synonyms	ARTD13, FLB6421, FLJ13288, MGC48898, PARP13, ZAP, ZC3H2, ZC3HDC2
Chromosome	7: 139043515-139132122
Predicted location	Intracellular
Essential gene	No
Protein class	Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	RNA-binding
Biological process	Antiviral defense, Immunity, Innate immunity

Function

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.