TRA2B — Transformer 2 beta homolog

TRA2B belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TRA2B's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1 +12 more	View in SCUBA
CD8⁺ T cells	Nucleocytoplasmic Transport RNA processing & translation	KHDRBS1, KPNB1, MAT2A, NFATC2IP, RBMX, SNX5, SSR3	View in SCUBA
Endothelial	Notch Ligand Signaling Endothelial cell development	DLL1, ITM2A, KRT222, LTBR, MLKL, SLC2A3, ZC3HAV1, ZNF436	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 more	View in SCUBA
Gamma-delta T cells	mRNA Splicing Regulation RNA processing & translation	ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP +18 more
Innate lymphoid cells	Pyruvate Metabolism Metabolism	ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 more	View in SCUBA
Lymphatic endothelial	DNA Damage Response DNA/chromatin regulation	BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, MAFB +7 more	View in SCUBA
Macrophages	Splicing Factor Regulation Housekeeping	ARAP1, CCNL1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220 +12 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	ATF3, EGR1, GLA, HMGCS1, IER3, NR4A1, NUP58, PPP1R15B +3 more
Neutrophils	RNA Splicing Housekeeping	ATF4, FUS, HNRNPA2B1, HNRNPA3, IRF2BP2, SFPQ, SRSF3
Pericytes	Proteotoxic Stress Response Stress	BAG3, CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, HSPH1, SLC2A3 +1 more	View in SCUBA

About the gene

Synonyms	Htra2-beta, PPP1R156, SFRS10
Chromosome	3: 185914558-185938103
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Activator, Repressor, RNA-binding
Biological process	mRNA processing, mRNA splicing

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.