PLEC — Plectin
PLEC belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Angiogenic Identity Endothelial cell development | ACTN4, ADGRL4, APBB2, CAVIN1, CD93, CLEC14A, CLIC4, ESAM +5 more | View in SCUBA |
| Enterocytes | Stress-responsive transcription Stress | AAK1, ABTB2, LPIN2, RIGI, SKIL, TMCC3 | View in SCUBA |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4 +8 more | |
| Pericytes | Caveolae Organization Cytoskeletal | CAV1, CAV2, CAVIN1, PDLIM5, PLS3, SYNE2, UTRN | View in SCUBA |
About the gene
| Synonyms | EBS1, PCN, PLEC1, PLTN |
|---|---|
| Chromosome | 8: 143915153-143976734 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.