ER-Actin Cytoskeletal
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene GTF2I (general transcription factor II-I) regulates transcription and is also involved in calcium signaling. CSDE1 (cold shock domain containing E1) is an RNA binding protein regulating translation and mRNA stability. KTN1 (kinectin 1) anchors kinesin to the ER for ER-to-Golgi transport. WASF2 (WAVE2) is a key actin nucleation-promoting factor downstream of RAC1. SERINC1 is an ER membrane serine incorporator. IQGAP1 is a cytoskeletal scaffold linking RAC1/CDC42 to actin. SEC62 is an ER protein translocation component. MAP4K4 is a kinase regulating cytoskeletal dynamics and cell migration. A2M (alpha-2-macroglobulin) is a broad-spectrum protease inhibitor secreted by pericytes. The module combines ER membrane/translocation with actin cytoskeletal regulation, consistent with pericyte structural maintenance. Neighbor M10 shares ER/Golgi themes, supporting this interpretation.
Genes
A2M, CSDE1, GTF2I, IQGAP1, KTN1, MAP4K4, SEC62, SERINC1, WASF2
Most correlated modules
- Golgi Vesicular Trafficking · correlation 0.97
- mRNA Stability Regulation · correlation 0.95
- G-protein Signaling Scaffold · correlation 0.92
- RAS Cytoskeletal Signaling · correlation 0.90
- Immunoproteasome Induction · correlation 0.90
- Type I Interferon · correlation 0.89
- RNA Splicing Processing · correlation 0.87
- Caveolae Organization · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.