PDLIM5 — PDZ and LIM domain 5
PDLIM5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDLIM5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more | View in SCUBA |
| Enterocytes | STAT3/JNK signaling Inflammation | CDC42SE2, ETV6, KIAA0232, LRRC1, MAPK8, PELI1, STAT3, STK24 | View in SCUBA |
| Fibroblasts | Notch Fibroblast Activation Developmental | CORO1C, DIXDC1, DSTN, FHL1, MRGPRF, RBPJ, SH3BGRL, TCEAL3 +2 more | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
| Pericytes | Caveolae Organization Cytoskeletal | CAV1, CAV2, CAVIN1, PLEC, PLS3, SYNE2, UTRN | View in SCUBA |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | Enh, LIM |
|---|---|
| Chromosome | 4: 94451857-94668227 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.