CAVIN1 — Caveolae associated protein 1
CAVIN1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAVIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Angiogenic Identity Endothelial cell development | ACTN4, ADGRL4, APBB2, CD93, CLEC14A, CLIC4, ESAM, MYH9 +5 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Migration & adhesion | FNBP1, KLHL5, LDLRAD3, MAP3K20, PDLIM3, PHLDB2, PLEKHO1, PLP2 +6 more | View in SCUBA |
| Glial cells | AHR-Cytokine Activation Activation | AHR, BHLHE40, CDH19, HNRNPA3, IL6ST, ITPR1, RBM39, SYNE1 +1 more | View in SCUBA |
| Lymphatic endothelial | Caveolae Cytoskeletal Cytoskeletal | CALM1, CRIP2, CTSZ, DYNLL1, EPHX1, GSTK1, HOXD8, HOXD9 +7 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Pericytes | Caveolae Organization Cytoskeletal | CAV1, CAV2, PDLIM5, PLEC, PLS3, SYNE2, UTRN | View in SCUBA |
| Smooth muscle cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME +8 more | View in SCUBA |
About the gene
| Synonyms | cavin-1, CGL4, PTRF |
|---|---|
| Chromosome | 17: 42402449-42423256 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding, rRNA-binding |
| Biological process | Transcription, Transcription regulation, Transcription termination |
Function
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.